While the recommendation to pay particular attention in maintaining an adequate consumption iron would be always advisable in a dietary strategy, the use of iron supplements should be a cautious choice based on a careful hematological evaluation, mainly because of the possible health risks deriving from an unjustified treatment. With particular regard to the sport related supplementation, currently no standardized guidelines for iron administration are available and the decision if administrating or not oral iron in athletes is mainly based on empiric recommendations or on performance enhancing hopes. Recent studies have permitted to define a specific and sex-independent ferritin cut-off below which an oral iron supplementation is useful and advantageous and above which this practice would not be advisable because useless and potentially hazardous for the athlete's health. In fact, it is becoming scientifically clear that conditions characterized by a reduced transfer of dietary iron from duodenal enterocytes to plasma rises intracellular iron concentration. An oral iron supplementation in these conditions would be not only unnecessary but also potentially disadvantageous because of the likely side effects deriving from the increased intracellular iron concentration in the gastrointestinal tract including discomfort, nausea, vomiting, diarrhea, or constipation. Such side effects gain even more importance in athletes because of the negative consequences on training capacity and performances that they imply. A scientifically based approach and a possible study of new parameters should always guide clinicians to define the real necessity of iron supplementation. This approach may reduce possible contraindications and side effects linked to improper iron supplementation. In fact, an incorrect supplementation may negatively affect the performance, rather than improve it.SciVal Topic Prominence Topic: Iron | Athletes | iron supplementationProminence percentile: 81.605 Author keywordsIronPhysical activitySide effectsSportSupplementationISSN: 02128799CODEN: AMDEFSource Type: JournalOriginal language: EnglishDocument Type: ReviewReferences (73)View in search results format All Export Print E-mail Save to PDF Create bibliography1DeMaeyer, E., Adiels-Tegman, M.The prevalence of anaemia in the world(1985) World Health Statistics Quarterly, 38 (3), pp. 302-316. Cited 707 times.Check SFX for full text2Anttila, R., Cook, J.D., Siimes, M.A.Body iron stores decrease in boys during pubertal development: The transferrin receptor-ferritin ratio as an indicator of iron status(1997) Pediatric Research, 41 (2), pp. 224-228. Cited 30 times.http://www.nature.com/pr/index.htmldoi: 10.1203/00006450-199702000-00012Check SFX for full text View at Publisher3Bothwell, T., Charlton, R., Cook, J.D., Finch, C.A.(1979) Iron Metabolism in Man. Cited 818 times.Blackwell St. Louis 4Darshan, D., Frazer, D.M., Anderson, G.J.Molecular basis of iron-loading disorders(2010) Expert Reviews in Molecular Medicine, 12, art. no. e36. Cited 38 times.doi: 10.1017/S1462399410001687Check SFX for full text View at Publisher5Núñez, M.T.Regulatory mechanisms of intestinal iron absorption - Uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis(2010) BioFactors, 36 (2), pp. 88-97. Cited 17 times.doi: 10.1002/biof.84Check SFX for full text View at Publisher6Anderson, G.J., Frazer, D.M., McKie, A.T., Vulpe, C.D., Smith, A.Mechanisms of haem and non-haem iron absorption: Lessons from inherited disorders of iron metabolism(2005) BioMetals, 18 (4), pp. 339-348. Cited 39 times.doi: 10.1007/s10534-005-3708-8Check SFX for full text View at Publisher7Heeney, M.M., Andrews, N.C.Iron homeostasis and inherited iron overload disorders: An overview(2004) Hematology/Oncology Clinics of North America, 18 (6 SPEC.ISS.), pp. 1379-1403. Cited 35 times.http://www.journals.elsevier.com/hematology-oncology-clinics-of-north-america/doi: 10.1016/j.hoc.2004.06.018Check SFX for full text View at Publisher8Kemna, E.H.J.M., Tjalsma, H., Willems, H.L., Swinkels, D.W.Hepcidin: From discovery to differential diagnosis (Open Access)(2008) Haematologica, 93 (1), pp. 90-97. Cited 208 times.doi: 10.3324/haematol.11705Check SFX for full text View at Publisher9Piperno, A., Mariani, R., Trombini, P., Girelli, D.Hepcidin modulation in human diseases: From research to clinic (Open Access)(2009) World Journal of Gastroenterology, 15 (5), pp. 538-551. Cited 70 times.http://www.wjgnet.com/1007-9327/15/538.pdfdoi: 10.3748/wjg.15.538Check SFX for full text View at Publisher10De Domenico, I., Ward, D.M., Langelier, C., Vaughn, M.B., Nemeth, E., Sundquist, W.I., Ganz, T., (...), Kaplan, J.The molecular mechanism of hepcidin-mediated ferroportin down-regulation(2007) Molecular Biology of the Cell, 18 (7), pp. 2569-2578. Cited 299 times.doi: 10.1091/mbc.E07-01-0060Check SFX for full text View at Publisher11Fleming, M.D.The regulation of hepcidin and its effects on systemic and cellular iron metabolism. (Open Access)(2008) Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, pp. 151-158. Cited 82 times.doi: 10.1182/asheducation-2008.1.151Check SFX for full text View at Publisher12Farley, P.C., Foland, J.Iron deficiency anemia. How to diagnose and correct(1990) Postgraduate Medicine, 87 (2), pp. 89-96+101. 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Cited 20 times.http://www.biomedcentral.com/1752-0509/4/147doi: 10.1186/1752-0509-4-147Check SFX for full text View at Publisher16Shayeghi, M., Latunde-Dada, G.O., Oakhill, J.S., Laftah, A.H., Takeuchi, K., Halliday, N., Khan, Y., (...), McKie, A.T.Identification of an intestinal heme transporter (Open Access)(2005) Cell, 122 (5), pp. 789-801. Cited 445 times.doi: 10.1016/j.cell.2005.06.025Check SFX for full text View at Publisher17Garrick, M.D., Dolan, K.G., Horbinski, C., Ghio, A.J., Higgins, D., Porubcin, M., Moore, E.G., (...), Garrick, L.M.DMT1: A mammalian transporter for multiple metals(2003) BioMetals, 16 (1), pp. 41-54. Cited 222 times.doi: 10.1023/A:1020702213099Check SFX for full text View at Publisher18Gunshin, H., Mackenzie, B., Berger, U.V., Gunshin, Y., Romero, M.F., Boron, W.F., Nussberger, S., (...), Hediger, M.A.Cloning and characterization of a mammalian proton-coupled metal-ion transporter(1997) Nature, 388 (6641), pp. 482-488. Cited 2296 times.doi: 10.1038/41343Check SFX for full text View at Publisher19Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S.J., Moynihan, J., Paw, B.H., (...), Leonard I, Z.Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter(2000) Nature, 403 (6771), pp. 776-781. Cited 1143 times.doi: 10.1038/35001596Check SFX for full text View at Publisher20McKie, A.T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., (...), Simpson, R.J.A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation (Open Access)(2000) Molecular Cell, 5 (2), pp. 299-309. Cited 1037 times.www.molecule.orgdoi: 10.1016/S1097-2765(00)80425-6Check SFX for full text View at Publisher21Abboud, S., Haile, D.J.A novel mammalian iron-regulated protein involved in intracellular iron metabolism (Open Access)(2000) Journal of Biological Chemistry, 275 (26), pp. 19906-19912. 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Cited 19 times.Check SFX for full text View at Publisher28Theil, E.C., Goss, D.J.Living with iron (and oxygen): Questions and answers about iron homeostasis(2009) Chemical Reviews, 109 (10), pp. 4568-4579. Cited 134 times.http://pubs.acs.org/doi/pdfplus/10.1021/cr900052gdoi: 10.1021/cr900052gCheck SFX for full text View at Publisher29(2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Cited 2313 times.Institute of Medicine. Food and Nutrition Board,Washington, DC: National Academy Press 30Love, A.L., Billett, H.H.Obesity, bariatric surgery, and iron deficiency: True, true, true and related(2008) American Journal of Hematology, 83 (5), pp. 403-409. Cited 102 times.doi: 10.1002/ajh.21106Check SFX for full text View at Publisher31Alleyne, M., Horne, M.K., Miller, J.L.Individualized Treatment for Iron-deficiency Anemia in Adults(2008) American Journal of Medicine, 121 (11), pp. 943-948. Cited 104 times.doi: 10.1016/j.amjmed.2008.07.012Check SFX for full text View at Publisher32Maughan, R.J.Aerobic function(1992) Sport Sci Rev, 1, pp. 28-42. Cited 9 times. 33Nieman, D.C.(1999) Fitness and Sports Medicine: A Healthrelated Approach. Cited 40 times.Mountain View CA Mayfield Publishing Company 34Ruud, J.S.(1990) Vegetarianism: Implications for Athletes. Cited 3 times.Omaha: International Center for Sports Nutrition 35Kleiner, S.M.The role of meat in an athlete's diet: Its effect on key macro- and micronutrients(1995) Sports Sci Exch, 8, pp. 1-6. Cited 5 times. 36Havala, S., Dwyer, J.Position of the American dietetic association: Vegetarian diets(1993) Journal of the American Dietetic Association, 93 (11), pp. 1317-1319. 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Cited 71 times.Check SFX for full text View at Publisher48Celsing, F., Ekblom, B.Anemia causes a relative decrease in blood lactate concentration during exercise(1986) European Journal of Applied Physiology and Occupational Physiology, 55 (1), pp. 74-78. Cited 15 times.doi: 10.1007/BF00422897Check SFX for full text View at Publisher49Gardner, G.W., Edgerton, V.R., Senewiratne, B., Barnard, R.J., Ohira, Y.Physical work capacity and metabolic stress in subjects with iron deficiency anemia(1977) American Journal of Clinical Nutrition, 30 (6), pp. 910-917. Cited 151 times.Check SFX for full text View at Publisher50Tufts, D.A., Haas, J.D., Beard, J.L., Spielvogel, H.Distribution of hemoglobin and functional consequences of anemia in adult males at high altitude(1985) American Journal of Clinical Nutrition, 42 (1), pp. 1-11. 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Cited 4 times.Katzung BG, ed., Norwalk, CT Appleton & Lange 73Lauffer, R.B.Exercise as prevention: Do the health benefits derive in part from lower iron levels?(1991) Medical Hypotheses, 35 (2), pp. 103-107. Cited 29 times.doi: 10.1016/0306-9877(91)90031-SCheck SFX for full text View at Publisher Pigozzi, F.; Department of Health Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis 15, Italy; email:fabio.pigozzi@uniroma4.it © Copyright 2011 Elsevier B.V., All rights reserved. Back to results Previous 42of71 Next Top of pageMetrics Learn more about Article metrics in Scopus (opens in a new window)0 Citations in Scopus0 Field-Weighted Citation ImpactPlumX MetricsUsage, Captures, Mentions, Social Media and Citations beyond Scopus.

Iron supplementation in Sport activities

Borrione P;Grasso L;Pigozzi F.
2011-01-01

Abstract

While the recommendation to pay particular attention in maintaining an adequate consumption iron would be always advisable in a dietary strategy, the use of iron supplements should be a cautious choice based on a careful hematological evaluation, mainly because of the possible health risks deriving from an unjustified treatment. With particular regard to the sport related supplementation, currently no standardized guidelines for iron administration are available and the decision if administrating or not oral iron in athletes is mainly based on empiric recommendations or on performance enhancing hopes. Recent studies have permitted to define a specific and sex-independent ferritin cut-off below which an oral iron supplementation is useful and advantageous and above which this practice would not be advisable because useless and potentially hazardous for the athlete's health. In fact, it is becoming scientifically clear that conditions characterized by a reduced transfer of dietary iron from duodenal enterocytes to plasma rises intracellular iron concentration. An oral iron supplementation in these conditions would be not only unnecessary but also potentially disadvantageous because of the likely side effects deriving from the increased intracellular iron concentration in the gastrointestinal tract including discomfort, nausea, vomiting, diarrhea, or constipation. Such side effects gain even more importance in athletes because of the negative consequences on training capacity and performances that they imply. A scientifically based approach and a possible study of new parameters should always guide clinicians to define the real necessity of iron supplementation. This approach may reduce possible contraindications and side effects linked to improper iron supplementation. In fact, an incorrect supplementation may negatively affect the performance, rather than improve it.SciVal Topic Prominence Topic: Iron | Athletes | iron supplementationProminence percentile: 81.605 Author keywordsIronPhysical activitySide effectsSportSupplementationISSN: 02128799CODEN: AMDEFSource Type: JournalOriginal language: EnglishDocument Type: ReviewReferences (73)View in search results format All Export Print E-mail Save to PDF Create bibliography1DeMaeyer, E., Adiels-Tegman, M.The prevalence of anaemia in the world(1985) World Health Statistics Quarterly, 38 (3), pp. 302-316. Cited 707 times.Check SFX for full text2Anttila, R., Cook, J.D., Siimes, M.A.Body iron stores decrease in boys during pubertal development: The transferrin receptor-ferritin ratio as an indicator of iron status(1997) Pediatric Research, 41 (2), pp. 224-228. Cited 30 times.http://www.nature.com/pr/index.htmldoi: 10.1203/00006450-199702000-00012Check SFX for full text View at Publisher3Bothwell, T., Charlton, R., Cook, J.D., Finch, C.A.(1979) Iron Metabolism in Man. Cited 818 times.Blackwell St. Louis 4Darshan, D., Frazer, D.M., Anderson, G.J.Molecular basis of iron-loading disorders(2010) Expert Reviews in Molecular Medicine, 12, art. no. e36. Cited 38 times.doi: 10.1017/S1462399410001687Check SFX for full text View at Publisher5Núñez, M.T.Regulatory mechanisms of intestinal iron absorption - Uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis(2010) BioFactors, 36 (2), pp. 88-97. Cited 17 times.doi: 10.1002/biof.84Check SFX for full text View at Publisher6Anderson, G.J., Frazer, D.M., McKie, A.T., Vulpe, C.D., Smith, A.Mechanisms of haem and non-haem iron absorption: Lessons from inherited disorders of iron metabolism(2005) BioMetals, 18 (4), pp. 339-348. Cited 39 times.doi: 10.1007/s10534-005-3708-8Check SFX for full text View at Publisher7Heeney, M.M., Andrews, N.C.Iron homeostasis and inherited iron overload disorders: An overview(2004) Hematology/Oncology Clinics of North America, 18 (6 SPEC.ISS.), pp. 1379-1403. Cited 35 times.http://www.journals.elsevier.com/hematology-oncology-clinics-of-north-america/doi: 10.1016/j.hoc.2004.06.018Check SFX for full text View at Publisher8Kemna, E.H.J.M., Tjalsma, H., Willems, H.L., Swinkels, D.W.Hepcidin: From discovery to differential diagnosis (Open Access)(2008) Haematologica, 93 (1), pp. 90-97. Cited 208 times.doi: 10.3324/haematol.11705Check SFX for full text View at Publisher9Piperno, A., Mariani, R., Trombini, P., Girelli, D.Hepcidin modulation in human diseases: From research to clinic (Open Access)(2009) World Journal of Gastroenterology, 15 (5), pp. 538-551. 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