While the recommendation to pay particular attention in maintaining an adequate consumption iron would be always advisable in a dietary strategy, the use of iron supplements should be a cautious choice based on a careful hematological evaluation, mainly because of the possible health risks deriving from an unjustified treatment. With particular regard to the sport related supplementation, currently no standardized guidelines for iron administration are available and the decision if administrating or not oral iron in athletes is mainly based on empiric recommendations or on performance enhancing hopes. Recent studies have permitted to define a specific and sex-independent ferritin cut-off below which an oral iron supplementation is useful and advantageous and above which this practice would not be advisable because useless and potentially hazardous for the athlete's health. In fact, it is becoming scientifically clear that conditions characterized by a reduced transfer of dietary iron from duodenal enterocytes to plasma rises intracellular iron concentration. An oral iron supplementation in these conditions would be not only unnecessary but also potentially disadvantageous because of the likely side effects deriving from the increased intracellular iron concentration in the gastrointestinal tract including discomfort, nausea, vomiting, diarrhea, or constipation. Such side effects gain even more importance in athletes because of the negative consequences on training capacity and performances that they imply. A scientifically based approach and a possible study of new parameters should always guide clinicians to define the real necessity of iron supplementation. This approach may reduce possible contraindications and side effects linked to improper iron supplementation. In fact, an incorrect supplementation may negatively affect the performance, rather than improve it.SciVal Topic Prominence Topic: Iron | Athletes | iron supplementationProminence percentile: 81.605 Author keywordsIronPhysical activitySide effectsSportSupplementationISSN: 02128799CODEN: AMDEFSource Type: JournalOriginal language: EnglishDocument Type: ReviewReferences (73)View in search results format All Export Print E-mail Save to PDF Create bibliography1DeMaeyer, E., Adiels-Tegman, M.The prevalence of anaemia in the world(1985) World Health Statistics Quarterly, 38 (3), pp. 302-316. Cited 707 times.Check SFX for full text2Anttila, R., Cook, J.D., Siimes, M.A.Body iron stores decrease in boys during pubertal development: The transferrin receptor-ferritin ratio as an indicator of iron status(1997) Pediatric Research, 41 (2), pp. 224-228. Cited 30 times.http://www.nature.com/pr/index.htmldoi: 10.1203/00006450-199702000-00012Check SFX for full text View at Publisher3Bothwell, T., Charlton, R., Cook, J.D., Finch, C.A.(1979) Iron Metabolism in Man. Cited 818 times.Blackwell St. Louis 4Darshan, D., Frazer, D.M., Anderson, G.J.Molecular basis of iron-loading disorders(2010) Expert Reviews in Molecular Medicine, 12, art. no. e36. Cited 38 times.doi: 10.1017/S1462399410001687Check SFX for full text View at Publisher5Núñez, M.T.Regulatory mechanisms of intestinal iron absorption - Uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis(2010) BioFactors, 36 (2), pp. 88-97. Cited 17 times.doi: 10.1002/biof.84Check SFX for full text View at Publisher6Anderson, G.J., Frazer, D.M., McKie, A.T., Vulpe, C.D., Smith, A.Mechanisms of haem and non-haem iron absorption: Lessons from inherited disorders of iron metabolism(2005) BioMetals, 18 (4), pp. 339-348. Cited 39 times.doi: 10.1007/s10534-005-3708-8Check SFX for full text View at Publisher7Heeney, M.M., Andrews, N.C.Iron homeostasis and inherited iron overload disorders: An overview(2004) Hematology/Oncology Clinics of North America, 18 (6 SPEC.ISS.), pp. 1379-1403. Cited 35 times.http://www.journals.elsevier.com/hematology-oncology-clinics-of-north-america/doi: 10.1016/j.hoc.2004.06.018Check SFX for full text View at Publisher8Kemna, E.H.J.M., Tjalsma, H., Willems, H.L., Swinkels, D.W.Hepcidin: From discovery to differential diagnosis (Open Access)(2008) Haematologica, 93 (1), pp. 90-97. Cited 208 times.doi: 10.3324/haematol.11705Check SFX for full text View at Publisher9Piperno, A., Mariani, R., Trombini, P., Girelli, D.Hepcidin modulation in human diseases: From research to clinic (Open Access)(2009) World Journal of Gastroenterology, 15 (5), pp. 538-551. Cited 70 times.http://www.wjgnet.com/1007-9327/15/538.pdfdoi: 10.3748/wjg.15.538Check SFX for full text View at Publisher10De Domenico, I., Ward, D.M., Langelier, C., Vaughn, M.B., Nemeth, E., Sundquist, W.I., Ganz, T., (...), Kaplan, J.The molecular mechanism of hepcidin-mediated ferroportin down-regulation(2007) Molecular Biology of the Cell, 18 (7), pp. 2569-2578. Cited 299 times.doi: 10.1091/mbc.E07-01-0060Check SFX for full text View at Publisher11Fleming, M.D.The regulation of hepcidin and its effects on systemic and cellular iron metabolism. (Open Access)(2008) Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, pp. 151-158. Cited 82 times.doi: 10.1182/asheducation-2008.1.151Check SFX for full text View at Publisher12Farley, P.C., Foland, J.Iron deficiency anemia. How to diagnose and correct(1990) Postgraduate Medicine, 87 (2), pp. 89-96+101. Cited 11 times.doi: 10.1080/00325481.1990.11704556Check SFX for full text View at Publisher13Cook, J.D.Diagnosis and management of iron-deficiency anaemia(2005) Best Practice and Research: Clinical Haematology, 18 (2 SPEC. ISS.), pp. 319-332. Cited 274 times.http://www.elsevier.com/inca/publications/store/6/2/3/0/0/3/index.httdoi: 10.1016/j.beha.2004.08.022Check SFX for full text View at Publisher14Looker, A.C., Dallman, P.R., Carroll, M.D., Gunter, E.W., Johnson, C.L.Prevalence of iron deficiency in the United States(1997) Journal of the American Medical Association, 277 (12), pp. 973-976. Cited 917 times.Check SFX for full text View at Publisher15Salgado, J.C., Olivera-Nappa, A., Gerdtzen, Z.P., Tapia, V., Theil, E.C., Conca, C., Nuñez, M.T.Mathematical modeling of the dynamic storage of iron in ferritin (Open Access)(2010) BMC Systems Biology, 4, art. no. 147. Cited 20 times.http://www.biomedcentral.com/1752-0509/4/147doi: 10.1186/1752-0509-4-147Check SFX for full text View at Publisher16Shayeghi, M., Latunde-Dada, G.O., Oakhill, J.S., Laftah, A.H., Takeuchi, K., Halliday, N., Khan, Y., (...), McKie, A.T.Identification of an intestinal heme transporter (Open Access)(2005) Cell, 122 (5), pp. 789-801. Cited 445 times.doi: 10.1016/j.cell.2005.06.025Check SFX for full text View at Publisher17Garrick, M.D., Dolan, K.G., Horbinski, C., Ghio, A.J., Higgins, D., Porubcin, M., Moore, E.G., (...), Garrick, L.M.DMT1: A mammalian transporter for multiple metals(2003) BioMetals, 16 (1), pp. 41-54. Cited 222 times.doi: 10.1023/A:1020702213099Check SFX for full text View at Publisher18Gunshin, H., Mackenzie, B., Berger, U.V., Gunshin, Y., Romero, M.F., Boron, W.F., Nussberger, S., (...), Hediger, M.A.Cloning and characterization of a mammalian proton-coupled metal-ion transporter(1997) Nature, 388 (6641), pp. 482-488. Cited 2296 times.doi: 10.1038/41343Check SFX for full text View at Publisher19Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S.J., Moynihan, J., Paw, B.H., (...), Leonard I, Z.Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter(2000) Nature, 403 (6771), pp. 776-781. Cited 1143 times.doi: 10.1038/35001596Check SFX for full text View at Publisher20McKie, A.T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., (...), Simpson, R.J.A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation (Open Access)(2000) Molecular Cell, 5 (2), pp. 299-309. Cited 1037 times.www.molecule.orgdoi: 10.1016/S1097-2765(00)80425-6Check SFX for full text View at Publisher21Abboud, S., Haile, D.J.A novel mammalian iron-regulated protein involved in intracellular iron metabolism (Open Access)(2000) Journal of Biological Chemistry, 275 (26), pp. 19906-19912. Cited 911 times.doi: 10.1074/jbc.M000713200Check SFX for full text View at Publisher22Linder, M.C., Zerounian, N.R., Moriya, M., Malpe, R.Iron and copper homeostasis and intestinal absorption using the Caco2 cell model(2003) BioMetals, 16 (1), pp. 145-160. Cited 26 times.doi: 10.1023/A:1020729831696Check SFX for full text View at Publisher23Sheehan, R.G., Frenkel, E.P.The control of iron absorption by the gastrointestinal mucosal cell. (Open Access)(1972) The Journal of clinical investigation, 51 (2), pp. 224-231. Cited 30 times.doi: 10.1172/JCI106807Check SFX for full text View at Publisher24Liu, X., Theil, E.C.Ferritins: Dynamic management of biological iron and oxygen chemistry(2005) Accounts of Chemical Research, 38 (3), pp. 167-175. Cited 335 times.doi: 10.1021/ar0302336Check SFX for full text View at Publisher25Harrison, P.M., Arosio, P.The ferritins: Molecular properties, iron storage function and cellular regulation (Open Access)(1996) Biochimica et Biophysica Acta - Bioenergetics, 1275 (3), pp. 161-203. Cited 1876 times.www.elsevier.com/locate/bbabiodoi: 10.1016/0005-2728(96)00022-9Check SFX for full text View at Publisher26Linder, M.C., Dunn, V., Isaacs, E., Jones, D., Lim, S., Van Volkom, M., Munro, H.N.Ferritin and intestinal iron absorption: pancreatic enzymes and free iron(1975) American Journal of Physiology, 228 (1), pp. 196-204. Cited 25 times.Check SFX for full text View at Publisher27Oates, P.S., Morgan, E.H.Ferritin gene expression and transferrin receptor activity in intestine of rats with varying iron stores(1997) American Journal of Physiology - Gastrointestinal and Liver Physiology, 273 (3 36-3), pp. G636-G646. Cited 19 times.Check SFX for full text View at Publisher28Theil, E.C., Goss, D.J.Living with iron (and oxygen): Questions and answers about iron homeostasis(2009) Chemical Reviews, 109 (10), pp. 4568-4579. Cited 134 times.http://pubs.acs.org/doi/pdfplus/10.1021/cr900052gdoi: 10.1021/cr900052gCheck SFX for full text View at Publisher29(2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Cited 2313 times.Institute of Medicine. Food and Nutrition Board,Washington, DC: National Academy Press 30Love, A.L., Billett, H.H.Obesity, bariatric surgery, and iron deficiency: True, true, true and related(2008) American Journal of Hematology, 83 (5), pp. 403-409. Cited 102 times.doi: 10.1002/ajh.21106Check SFX for full text View at Publisher31Alleyne, M., Horne, M.K., Miller, J.L.Individualized Treatment for Iron-deficiency Anemia in Adults(2008) American Journal of Medicine, 121 (11), pp. 943-948. Cited 104 times.doi: 10.1016/j.amjmed.2008.07.012Check SFX for full text View at Publisher32Maughan, R.J.Aerobic function(1992) Sport Sci Rev, 1, pp. 28-42. Cited 9 times. 33Nieman, D.C.(1999) Fitness and Sports Medicine: A Healthrelated Approach. Cited 40 times.Mountain View CA Mayfield Publishing Company 34Ruud, J.S.(1990) Vegetarianism: Implications for Athletes. Cited 3 times.Omaha: International Center for Sports Nutrition 35Kleiner, S.M.The role of meat in an athlete's diet: Its effect on key macro- and micronutrients(1995) Sports Sci Exch, 8, pp. 1-6. Cited 5 times. 36Havala, S., Dwyer, J.Position of the American dietetic association: Vegetarian diets(1993) Journal of the American Dietetic Association, 93 (11), pp. 1317-1319. Cited 29 times.doi: 10.1016/0002-8223(93)91966-TCheck SFX for full text View at Publisher37Craig, W.J.Iron status of vegetarians (Open Access)(1994) American Journal of Clinical Nutrition, 59 (5 SUPPL.), pp. 1233S-1237S. Cited 84 times.http://www.ajcn.org/contents-by-date.2005.shtmldoi: 10.1093/ajcn/59.5.1233SCheck SFX for full text View at Publisher38Ehn, L., Carlmark, B., Höglund, S.Iron status in athletes involved in intense physical activity(1980) Medicine and Science in Sports and Exercise, 12 (1), pp. 61-64. Cited 113 times.Check SFX for full text View at Publisher39Keeffe, E.B., Lowe, D.K., Goss, J.R., Wayne, R.Gastrointestinal symptoms of marathon runners(1984) Western Journal of Medicine, 141 (4), pp. 481-484. Cited 63 times.Check SFX for full text40Bärtsch, P., Mairbäurl, H., Friedmann, B.Pseudoanemia in sports(1998) Therapeutische Umschau, 55 (4), pp. 251-255. Cited 12 times.Check SFX for full text41Balaban, E.P.Sports anemia(1992) Clinics in Sports Medicine, 11 (2), pp. 313-325. Cited 29 times.Check SFX for full text42Chatard, J.-C., Mujika, I., Guy, C., Lacour, J.-R.Anaemia and iron deficiency in athletes. Practical recommendations for treatment(1999) Sports Medicine, 27 (4), pp. 229-240. Cited 87 times.http://rd.springer.com/journal/40279doi: 10.2165/00007256-199927040-00003Check SFX for full text View at Publisher43Carlson, D.L., Mawdsley, R.H.Sports anemia: A review of the literature(1986) The American Journal of Sports Medicine, 14 (2), pp. 109-112. Cited 38 times.doi: 10.1177/036354658601400202Check SFX for full text View at Publisher44Mechrefe, A., Wexler, B., Feller, E.Sports anemia and gastrointestinal bleeding in endurance athletes.(1997) Medicine and health, Rhode Island, 80 (7), pp. 216-218. Cited 6 times.Check SFX for full text45Bizzaro, N.Study of variations in hematologic parameters in rugby players undergoing physical training at a high altitude(1989) Recenti Progressi in Medicina, 80 (5), pp. 237-240. Cited 3 times.Check SFX for full text46Kargotich, S., Goodman, C., Keast, D., Morton, A.R.The influence of exercise-induced plasma volume changes on the interpretation of biochemical parameters used for monitoring exercise, training and sport(1998) Sports Medicine, 26 (2), pp. 101-117. Cited 102 times.doi: 10.2165/00007256-199826020-00004Check SFX for full text View at Publisher47Celsing, F., Blomstrand, E., Werner, B., Pihlstedt, P., Ekblom, B.Effects of iron deficiency on endurance and muscle enzyme activity in man(1986) Medicine and Science in Sports and Exercise, 18 (2), pp. 156-161. Cited 71 times.Check SFX for full text View at Publisher48Celsing, F., Ekblom, B.Anemia causes a relative decrease in blood lactate concentration during exercise(1986) European Journal of Applied Physiology and Occupational Physiology, 55 (1), pp. 74-78. Cited 15 times.doi: 10.1007/BF00422897Check SFX for full text View at Publisher49Gardner, G.W., Edgerton, V.R., Senewiratne, B., Barnard, R.J., Ohira, Y.Physical work capacity and metabolic stress in subjects with iron deficiency anemia(1977) American Journal of Clinical Nutrition, 30 (6), pp. 910-917. Cited 151 times.Check SFX for full text View at Publisher50Tufts, D.A., Haas, J.D., Beard, J.L., Spielvogel, H.Distribution of hemoglobin and functional consequences of anemia in adult males at high altitude(1985) American Journal of Clinical Nutrition, 42 (1), pp. 1-11. Cited 51 times.doi: 10.1093/ajcn/42.1.1Check SFX for full text View at Publisher51Ascenzi, P., Bocedi, A., Visca, P., Altruda, F., Tolosano, E., Beringhelli, T., Fasano, M.Hemoglobin and heme scavenging (Open Access)(2005) IUBMB Life, 57 (11), pp. 749-759. Cited 144 times.doi: 10.1080/15216540500380871Check SFX for full text View at Publisher52Blum, S.M., Sherman, A.R., Boileau, R.A.The effects of fitness-type exercise on iron status in adult women (Open Access)(1986) American Journal of Clinical Nutrition, 43 (3), pp. 456-463. Cited 37 times.doi: 10.1093/ajcn/43.3.456Check SFX for full text View at Publisher53Jensen, C.A., Weaver, C.M., Sedlock, D.A.Iron supplementation and iron status in exercising young women(1991) The Journal of Nutritional Biochemistry, 2 (7), pp. 368-373. Cited 12 times.doi: 10.1016/0955-2863(91)90093-KCheck SFX for full text View at Publisher54Lyle, R.M., Weaver, C.M., Sedlock, D.A., Rajaram, S., Martin, B., Melby, C.L.Iron status in exercising women: The effect of oral iron therapy vs increased consumption of muscle foods(1992) American Journal of Clinical Nutrition, 56 (6), pp. 1049-1055. Cited 61 times.doi: 10.1093/ajcn/56.6.1049Check SFX for full text View at Publisher55Zoller, H., Vogel, W.Iron supplementation in athletes - First do no harm(2004) Nutrition, 20 (7-8), pp. 615-619. Cited 81 times.doi: 10.1016/j.nut.2004.04.006Check SFX for full text View at Publisher56Jenkins, R.R., Krause, K., Schofield, L.S.Influence of exercise on clearance of oxidant stress products and loosely bound iron(1993) Medicine and Science in Sports and Exercise, 25 (2), pp. 213-217. Cited 64 times.Check SFX for full text View at Publisher57Garza, D., Shrier, I., Kohl III, H.W., Ford, P., Brown, M., Matheson, G.O.The clinical value of serum ferritin tests in endurance athletes(1997) Clinical Journal of Sport Medicine, 7 (1), pp. 46-53. Cited 23 times.http://www.cjsportmed.com/doi: 10.1097/00042752-199701000-00009Check SFX for full text View at Publisher58Kohgo, Y., Ikuta, K., Ohtake, T., Torimoto, Y., Kato, J.Body iron metabolism and pathophysiology of iron overload (Open Access)(2008) International Journal of Hematology, 88 (1), pp. 7-15. Cited 225 times.doi: 10.1007/s12185-008-0120-5Check SFX for full text View at Publisher59Jacobs, A., Miller, F., Worwood, M., Beamish, M.R., Wardrop, C.A.J.Ferritin in the Serum of Normal Subjects and Patients with Iron Deficiency and Iron Overload (Open Access)(1972) British Medical Journal, 4 (5834), p. 206. Cited 176 times.doi: 10.1136/bmj.4.5834.206Check SFX for full text View at Publisher60Karamizrak, S.O.Evaluation of iron metabolism indices and their relation with physical work capacity in athletes (Open Access)(1996) British Journal of Sports Medicine, 30 (1), pp. 15-19. Cited 22 times.http://bjsm.bmjjournals.com/doi: 10.1136/bjsm.30.1.15Check SFX for full text View at Publisher61Samuelson, G., Lonnerdal, B., Kempe, B., Elverby, J.-E., Bratteby, L.-E.A follow-up study of serum ferritin and transferrin receptor concentrations in Swedish adolescents at age 17 years compared to age 15(2000) Acta Paediatrica, International Journal of Paediatrics, 89 (10), pp. 1162-1168. Cited 22 times.Check SFX for full text View at Publisher62Sham, R.L., Phatak, P.D., Nemeth, E., Ganz, T.Hereditary hemochromatosis due to resistance to hepcidin: High hepcidin concentrations in a family with C326S ferroportin mutation (Open Access)(2009) Blood, 114 (2), pp. 493-494. Cited 47 times.http://bloodjournal.hematologylibrary.org/cgi/reprint/114/2/493doi: 10.1182/blood-2009-04-216226Check SFX for full text View at Publisher63De Mast, Q., Nadjm, B., Reyburn, H., Kemna, E.H.J.M., Amos, B., Laarakkers, C.M.M., Silalye, S., (...), Van Der Ven, A.J.A.M.Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection (Open Access)(2009) Journal of Infectious Diseases, 199 (2), pp. 253-262. Cited 74 times.doi: 10.1086/595790Check SFX for full text View at Publisher64Brown, K., Subramony, C., May, W., Megason, G., Liu, H., Bishop, P., Walker, T., (...), Nowicki, M.J.Hepatic iron overload in children with sickle cell anemia on chronic transfusion therapy(2009) Journal of Pediatric Hematology/Oncology, 31 (5), pp. 309-312. Cited 34 times.doi: 10.1097/MPH.0b013e3181a1c143Check SFX for full text View at Publisher65Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E.T., Swinkels, D.W., Trinder, D.Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity(2009) European Journal of Applied Physiology, 106 (1), pp. 51-59. Cited 59 times.doi: 10.1007/s00421-009-0988-7Check SFX for full text View at Publisher66Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E.T., Swinkels, D.W., Trinder, D.Training surface and intensity: Inflammation, hemolysis, and hepcidin expression(2009) Medicine and Science in Sports and Exercise, 41 (5), pp. 1138-1145. Cited 70 times.doi: 10.1249/MSS.0b013e318192ce58Check SFX for full text View at Publisher67Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E.T., Swinkels, D.W., Trinder, D.Effects of exercise on hepcidin response and iron metabolism during recovery(2009) International Journal of Sport Nutrition and Exercise Metabolism, 19 (6), pp. 583-597. Cited 59 times.http://hk.humankinetics.com/eJournalMedia/pdfs/17609.pdfdoi: 10.1123/ijsnem.19.6.583Check SFX for full text View at Publisher68Roecker, L., Meier-Buttermilch, R., Brechtel, L., Nemeth, E., Ganz, T.Iron-regulatory protein hepcidin is increased in female athletes after a marathon(2005) European Journal of Applied Physiology, 95 (5-6), pp. 569-571. Cited 82 times.doi: 10.1007/s00421-005-0055-yCheck SFX for full text View at Publisher69Adamson, J.W.The anemia of inflammation/malignancy: mechanisms and management. (Open Access)(2008) Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, pp. 159-165. Cited 59 times.doi: 10.1182/asheducation-2008.1.159Check SFX for full text View at Publisher70Dascombe, B.J., Karunaratna, M., Cartoon, J., Fergie, B., Goodman, C.Nutritional supplementation habits and perceptions of elite athletes within a state-based sporting institute(2010) Journal of Science and Medicine in Sport, 13 (2), pp. 274-280. Cited 61 times.doi: 10.1016/j.jsams.2009.03.005Check SFX for full text View at Publisher71Ziauddin Hyder, S.M., Persson, L.Å., Chowdhury, A.M.R., Ekström, E.-C.Do side-effects reduce compliance to iron supplementation? A study of daily- and weekly-dose regimens in pregnancy(2002) Journal of Health Population and Nutrition, 20 (2), pp. 175-179. Cited 77 times.Check SFX for full text View at Publisher72Ries, C.A., Santi, D.V.Agents used in anemias(1992) Basic and Clinical Pharmacology, pp. 453-459. Cited 4 times.Katzung BG, ed., Norwalk, CT Appleton & Lange 73Lauffer, R.B.Exercise as prevention: Do the health benefits derive in part from lower iron levels?(1991) Medical Hypotheses, 35 (2), pp. 103-107. Cited 29 times.doi: 10.1016/0306-9877(91)90031-SCheck SFX for full text View at Publisher Pigozzi, F.; Department of Health Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis 15, Italy; email:fabio.pigozzi@uniroma4.it © Copyright 2011 Elsevier B.V., All rights reserved. Back to results Previous 42of71 Next Top of pageMetrics Learn more about Article metrics in Scopus (opens in a new window)0 Citations in Scopus0 Field-Weighted Citation ImpactPlumX MetricsUsage, Captures, Mentions, Social Media and Citations beyond Scopus.
Iron supplementation in Sport activities
Borrione P;Grasso L;Pigozzi F.
2011-01-01
Abstract
While the recommendation to pay particular attention in maintaining an adequate consumption iron would be always advisable in a dietary strategy, the use of iron supplements should be a cautious choice based on a careful hematological evaluation, mainly because of the possible health risks deriving from an unjustified treatment. With particular regard to the sport related supplementation, currently no standardized guidelines for iron administration are available and the decision if administrating or not oral iron in athletes is mainly based on empiric recommendations or on performance enhancing hopes. Recent studies have permitted to define a specific and sex-independent ferritin cut-off below which an oral iron supplementation is useful and advantageous and above which this practice would not be advisable because useless and potentially hazardous for the athlete's health. In fact, it is becoming scientifically clear that conditions characterized by a reduced transfer of dietary iron from duodenal enterocytes to plasma rises intracellular iron concentration. An oral iron supplementation in these conditions would be not only unnecessary but also potentially disadvantageous because of the likely side effects deriving from the increased intracellular iron concentration in the gastrointestinal tract including discomfort, nausea, vomiting, diarrhea, or constipation. Such side effects gain even more importance in athletes because of the negative consequences on training capacity and performances that they imply. A scientifically based approach and a possible study of new parameters should always guide clinicians to define the real necessity of iron supplementation. This approach may reduce possible contraindications and side effects linked to improper iron supplementation. In fact, an incorrect supplementation may negatively affect the performance, rather than improve it.SciVal Topic Prominence Topic: Iron | Athletes | iron supplementationProminence percentile: 81.605 Author keywordsIronPhysical activitySide effectsSportSupplementationISSN: 02128799CODEN: AMDEFSource Type: JournalOriginal language: EnglishDocument Type: ReviewReferences (73)View in search results format All Export Print E-mail Save to PDF Create bibliography1DeMaeyer, E., Adiels-Tegman, M.The prevalence of anaemia in the world(1985) World Health Statistics Quarterly, 38 (3), pp. 302-316. Cited 707 times.Check SFX for full text2Anttila, R., Cook, J.D., Siimes, M.A.Body iron stores decrease in boys during pubertal development: The transferrin receptor-ferritin ratio as an indicator of iron status(1997) Pediatric Research, 41 (2), pp. 224-228. Cited 30 times.http://www.nature.com/pr/index.htmldoi: 10.1203/00006450-199702000-00012Check SFX for full text View at Publisher3Bothwell, T., Charlton, R., Cook, J.D., Finch, C.A.(1979) Iron Metabolism in Man. Cited 818 times.Blackwell St. Louis 4Darshan, D., Frazer, D.M., Anderson, G.J.Molecular basis of iron-loading disorders(2010) Expert Reviews in Molecular Medicine, 12, art. no. e36. Cited 38 times.doi: 10.1017/S1462399410001687Check SFX for full text View at Publisher5Núñez, M.T.Regulatory mechanisms of intestinal iron absorption - Uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis(2010) BioFactors, 36 (2), pp. 88-97. Cited 17 times.doi: 10.1002/biof.84Check SFX for full text View at Publisher6Anderson, G.J., Frazer, D.M., McKie, A.T., Vulpe, C.D., Smith, A.Mechanisms of haem and non-haem iron absorption: Lessons from inherited disorders of iron metabolism(2005) BioMetals, 18 (4), pp. 339-348. Cited 39 times.doi: 10.1007/s10534-005-3708-8Check SFX for full text View at Publisher7Heeney, M.M., Andrews, N.C.Iron homeostasis and inherited iron overload disorders: An overview(2004) Hematology/Oncology Clinics of North America, 18 (6 SPEC.ISS.), pp. 1379-1403. Cited 35 times.http://www.journals.elsevier.com/hematology-oncology-clinics-of-north-america/doi: 10.1016/j.hoc.2004.06.018Check SFX for full text View at Publisher8Kemna, E.H.J.M., Tjalsma, H., Willems, H.L., Swinkels, D.W.Hepcidin: From discovery to differential diagnosis (Open Access)(2008) Haematologica, 93 (1), pp. 90-97. Cited 208 times.doi: 10.3324/haematol.11705Check SFX for full text View at Publisher9Piperno, A., Mariani, R., Trombini, P., Girelli, D.Hepcidin modulation in human diseases: From research to clinic (Open Access)(2009) World Journal of Gastroenterology, 15 (5), pp. 538-551. Cited 70 times.http://www.wjgnet.com/1007-9327/15/538.pdfdoi: 10.3748/wjg.15.538Check SFX for full text View at Publisher10De Domenico, I., Ward, D.M., Langelier, C., Vaughn, M.B., Nemeth, E., Sundquist, W.I., Ganz, T., (...), Kaplan, J.The molecular mechanism of hepcidin-mediated ferroportin down-regulation(2007) Molecular Biology of the Cell, 18 (7), pp. 2569-2578. Cited 299 times.doi: 10.1091/mbc.E07-01-0060Check SFX for full text View at Publisher11Fleming, M.D.The regulation of hepcidin and its effects on systemic and cellular iron metabolism. (Open Access)(2008) Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, pp. 151-158. Cited 82 times.doi: 10.1182/asheducation-2008.1.151Check SFX for full text View at Publisher12Farley, P.C., Foland, J.Iron deficiency anemia. How to diagnose and correct(1990) Postgraduate Medicine, 87 (2), pp. 89-96+101. Cited 11 times.doi: 10.1080/00325481.1990.11704556Check SFX for full text View at Publisher13Cook, J.D.Diagnosis and management of iron-deficiency anaemia(2005) Best Practice and Research: Clinical Haematology, 18 (2 SPEC. ISS.), pp. 319-332. Cited 274 times.http://www.elsevier.com/inca/publications/store/6/2/3/0/0/3/index.httdoi: 10.1016/j.beha.2004.08.022Check SFX for full text View at Publisher14Looker, A.C., Dallman, P.R., Carroll, M.D., Gunter, E.W., Johnson, C.L.Prevalence of iron deficiency in the United States(1997) Journal of the American Medical Association, 277 (12), pp. 973-976. Cited 917 times.Check SFX for full text View at Publisher15Salgado, J.C., Olivera-Nappa, A., Gerdtzen, Z.P., Tapia, V., Theil, E.C., Conca, C., Nuñez, M.T.Mathematical modeling of the dynamic storage of iron in ferritin (Open Access)(2010) BMC Systems Biology, 4, art. no. 147. Cited 20 times.http://www.biomedcentral.com/1752-0509/4/147doi: 10.1186/1752-0509-4-147Check SFX for full text View at Publisher16Shayeghi, M., Latunde-Dada, G.O., Oakhill, J.S., Laftah, A.H., Takeuchi, K., Halliday, N., Khan, Y., (...), McKie, A.T.Identification of an intestinal heme transporter (Open Access)(2005) Cell, 122 (5), pp. 789-801. Cited 445 times.doi: 10.1016/j.cell.2005.06.025Check SFX for full text View at Publisher17Garrick, M.D., Dolan, K.G., Horbinski, C., Ghio, A.J., Higgins, D., Porubcin, M., Moore, E.G., (...), Garrick, L.M.DMT1: A mammalian transporter for multiple metals(2003) BioMetals, 16 (1), pp. 41-54. Cited 222 times.doi: 10.1023/A:1020702213099Check SFX for full text View at Publisher18Gunshin, H., Mackenzie, B., Berger, U.V., Gunshin, Y., Romero, M.F., Boron, W.F., Nussberger, S., (...), Hediger, M.A.Cloning and characterization of a mammalian proton-coupled metal-ion transporter(1997) Nature, 388 (6641), pp. 482-488. Cited 2296 times.doi: 10.1038/41343Check SFX for full text View at Publisher19Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S.J., Moynihan, J., Paw, B.H., (...), Leonard I, Z.Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter(2000) Nature, 403 (6771), pp. 776-781. Cited 1143 times.doi: 10.1038/35001596Check SFX for full text View at Publisher20McKie, A.T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., (...), Simpson, R.J.A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation (Open Access)(2000) Molecular Cell, 5 (2), pp. 299-309. Cited 1037 times.www.molecule.orgdoi: 10.1016/S1097-2765(00)80425-6Check SFX for full text View at Publisher21Abboud, S., Haile, D.J.A novel mammalian iron-regulated protein involved in intracellular iron metabolism (Open Access)(2000) Journal of Biological Chemistry, 275 (26), pp. 19906-19912. Cited 911 times.doi: 10.1074/jbc.M000713200Check SFX for full text View at Publisher22Linder, M.C., Zerounian, N.R., Moriya, M., Malpe, R.Iron and copper homeostasis and intestinal absorption using the Caco2 cell model(2003) BioMetals, 16 (1), pp. 145-160. Cited 26 times.doi: 10.1023/A:1020729831696Check SFX for full text View at Publisher23Sheehan, R.G., Frenkel, E.P.The control of iron absorption by the gastrointestinal mucosal cell. (Open Access)(1972) The Journal of clinical investigation, 51 (2), pp. 224-231. Cited 30 times.doi: 10.1172/JCI106807Check SFX for full text View at Publisher24Liu, X., Theil, E.C.Ferritins: Dynamic management of biological iron and oxygen chemistry(2005) Accounts of Chemical Research, 38 (3), pp. 167-175. Cited 335 times.doi: 10.1021/ar0302336Check SFX for full text View at Publisher25Harrison, P.M., Arosio, P.The ferritins: Molecular properties, iron storage function and cellular regulation (Open Access)(1996) Biochimica et Biophysica Acta - Bioenergetics, 1275 (3), pp. 161-203. Cited 1876 times.www.elsevier.com/locate/bbabiodoi: 10.1016/0005-2728(96)00022-9Check SFX for full text View at Publisher26Linder, M.C., Dunn, V., Isaacs, E., Jones, D., Lim, S., Van Volkom, M., Munro, H.N.Ferritin and intestinal iron absorption: pancreatic enzymes and free iron(1975) American Journal of Physiology, 228 (1), pp. 196-204. Cited 25 times.Check SFX for full text View at Publisher27Oates, P.S., Morgan, E.H.Ferritin gene expression and transferrin receptor activity in intestine of rats with varying iron stores(1997) American Journal of Physiology - Gastrointestinal and Liver Physiology, 273 (3 36-3), pp. G636-G646. Cited 19 times.Check SFX for full text View at Publisher28Theil, E.C., Goss, D.J.Living with iron (and oxygen): Questions and answers about iron homeostasis(2009) Chemical Reviews, 109 (10), pp. 4568-4579. Cited 134 times.http://pubs.acs.org/doi/pdfplus/10.1021/cr900052gdoi: 10.1021/cr900052gCheck SFX for full text View at Publisher29(2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Cited 2313 times.Institute of Medicine. Food and Nutrition Board,Washington, DC: National Academy Press 30Love, A.L., Billett, H.H.Obesity, bariatric surgery, and iron deficiency: True, true, true and related(2008) American Journal of Hematology, 83 (5), pp. 403-409. Cited 102 times.doi: 10.1002/ajh.21106Check SFX for full text View at Publisher31Alleyne, M., Horne, M.K., Miller, J.L.Individualized Treatment for Iron-deficiency Anemia in Adults(2008) American Journal of Medicine, 121 (11), pp. 943-948. Cited 104 times.doi: 10.1016/j.amjmed.2008.07.012Check SFX for full text View at Publisher32Maughan, R.J.Aerobic function(1992) Sport Sci Rev, 1, pp. 28-42. Cited 9 times. 33Nieman, D.C.(1999) Fitness and Sports Medicine: A Healthrelated Approach. Cited 40 times.Mountain View CA Mayfield Publishing Company 34Ruud, J.S.(1990) Vegetarianism: Implications for Athletes. Cited 3 times.Omaha: International Center for Sports Nutrition 35Kleiner, S.M.The role of meat in an athlete's diet: Its effect on key macro- and micronutrients(1995) Sports Sci Exch, 8, pp. 1-6. Cited 5 times. 36Havala, S., Dwyer, J.Position of the American dietetic association: Vegetarian diets(1993) Journal of the American Dietetic Association, 93 (11), pp. 1317-1319. Cited 29 times.doi: 10.1016/0002-8223(93)91966-TCheck SFX for full text View at Publisher37Craig, W.J.Iron status of vegetarians (Open Access)(1994) American Journal of Clinical Nutrition, 59 (5 SUPPL.), pp. 1233S-1237S. Cited 84 times.http://www.ajcn.org/contents-by-date.2005.shtmldoi: 10.1093/ajcn/59.5.1233SCheck SFX for full text View at Publisher38Ehn, L., Carlmark, B., Höglund, S.Iron status in athletes involved in intense physical activity(1980) Medicine and Science in Sports and Exercise, 12 (1), pp. 61-64. Cited 113 times.Check SFX for full text View at Publisher39Keeffe, E.B., Lowe, D.K., Goss, J.R., Wayne, R.Gastrointestinal symptoms of marathon runners(1984) Western Journal of Medicine, 141 (4), pp. 481-484. Cited 63 times.Check SFX for full text40Bärtsch, P., Mairbäurl, H., Friedmann, B.Pseudoanemia in sports(1998) Therapeutische Umschau, 55 (4), pp. 251-255. Cited 12 times.Check SFX for full text41Balaban, E.P.Sports anemia(1992) Clinics in Sports Medicine, 11 (2), pp. 313-325. Cited 29 times.Check SFX for full text42Chatard, J.-C., Mujika, I., Guy, C., Lacour, J.-R.Anaemia and iron deficiency in athletes. Practical recommendations for treatment(1999) Sports Medicine, 27 (4), pp. 229-240. Cited 87 times.http://rd.springer.com/journal/40279doi: 10.2165/00007256-199927040-00003Check SFX for full text View at Publisher43Carlson, D.L., Mawdsley, R.H.Sports anemia: A review of the literature(1986) The American Journal of Sports Medicine, 14 (2), pp. 109-112. Cited 38 times.doi: 10.1177/036354658601400202Check SFX for full text View at Publisher44Mechrefe, A., Wexler, B., Feller, E.Sports anemia and gastrointestinal bleeding in endurance athletes.(1997) Medicine and health, Rhode Island, 80 (7), pp. 216-218. Cited 6 times.Check SFX for full text45Bizzaro, N.Study of variations in hematologic parameters in rugby players undergoing physical training at a high altitude(1989) Recenti Progressi in Medicina, 80 (5), pp. 237-240. Cited 3 times.Check SFX for full text46Kargotich, S., Goodman, C., Keast, D., Morton, A.R.The influence of exercise-induced plasma volume changes on the interpretation of biochemical parameters used for monitoring exercise, training and sport(1998) Sports Medicine, 26 (2), pp. 101-117. Cited 102 times.doi: 10.2165/00007256-199826020-00004Check SFX for full text View at Publisher47Celsing, F., Blomstrand, E., Werner, B., Pihlstedt, P., Ekblom, B.Effects of iron deficiency on endurance and muscle enzyme activity in man(1986) Medicine and Science in Sports and Exercise, 18 (2), pp. 156-161. Cited 71 times.Check SFX for full text View at Publisher48Celsing, F., Ekblom, B.Anemia causes a relative decrease in blood lactate concentration during exercise(1986) European Journal of Applied Physiology and Occupational Physiology, 55 (1), pp. 74-78. Cited 15 times.doi: 10.1007/BF00422897Check SFX for full text View at Publisher49Gardner, G.W., Edgerton, V.R., Senewiratne, B., Barnard, R.J., Ohira, Y.Physical work capacity and metabolic stress in subjects with iron deficiency anemia(1977) American Journal of Clinical Nutrition, 30 (6), pp. 910-917. Cited 151 times.Check SFX for full text View at Publisher50Tufts, D.A., Haas, J.D., Beard, J.L., Spielvogel, H.Distribution of hemoglobin and functional consequences of anemia in adult males at high altitude(1985) American Journal of Clinical Nutrition, 42 (1), pp. 1-11. Cited 51 times.doi: 10.1093/ajcn/42.1.1Check SFX for full text View at Publisher51Ascenzi, P., Bocedi, A., Visca, P., Altruda, F., Tolosano, E., Beringhelli, T., Fasano, M.Hemoglobin and heme scavenging (Open Access)(2005) IUBMB Life, 57 (11), pp. 749-759. Cited 144 times.doi: 10.1080/15216540500380871Check SFX for full text View at Publisher52Blum, S.M., Sherman, A.R., Boileau, R.A.The effects of fitness-type exercise on iron status in adult women (Open Access)(1986) American Journal of Clinical Nutrition, 43 (3), pp. 456-463. Cited 37 times.doi: 10.1093/ajcn/43.3.456Check SFX for full text View at Publisher53Jensen, C.A., Weaver, C.M., Sedlock, D.A.Iron supplementation and iron status in exercising young women(1991) The Journal of Nutritional Biochemistry, 2 (7), pp. 368-373. Cited 12 times.doi: 10.1016/0955-2863(91)90093-KCheck SFX for full text View at Publisher54Lyle, R.M., Weaver, C.M., Sedlock, D.A., Rajaram, S., Martin, B., Melby, C.L.Iron status in exercising women: The effect of oral iron therapy vs increased consumption of muscle foods(1992) American Journal of Clinical Nutrition, 56 (6), pp. 1049-1055. Cited 61 times.doi: 10.1093/ajcn/56.6.1049Check SFX for full text View at Publisher55Zoller, H., Vogel, W.Iron supplementation in athletes - First do no harm(2004) Nutrition, 20 (7-8), pp. 615-619. Cited 81 times.doi: 10.1016/j.nut.2004.04.006Check SFX for full text View at Publisher56Jenkins, R.R., Krause, K., Schofield, L.S.Influence of exercise on clearance of oxidant stress products and loosely bound iron(1993) Medicine and Science in Sports and Exercise, 25 (2), pp. 213-217. Cited 64 times.Check SFX for full text View at Publisher57Garza, D., Shrier, I., Kohl III, H.W., Ford, P., Brown, M., Matheson, G.O.The clinical value of serum ferritin tests in endurance athletes(1997) Clinical Journal of Sport Medicine, 7 (1), pp. 46-53. Cited 23 times.http://www.cjsportmed.com/doi: 10.1097/00042752-199701000-00009Check SFX for full text View at Publisher58Kohgo, Y., Ikuta, K., Ohtake, T., Torimoto, Y., Kato, J.Body iron metabolism and pathophysiology of iron overload (Open Access)(2008) International Journal of Hematology, 88 (1), pp. 7-15. Cited 225 times.doi: 10.1007/s12185-008-0120-5Check SFX for full text View at Publisher59Jacobs, A., Miller, F., Worwood, M., Beamish, M.R., Wardrop, C.A.J.Ferritin in the Serum of Normal Subjects and Patients with Iron Deficiency and Iron Overload (Open Access)(1972) British Medical Journal, 4 (5834), p. 206. Cited 176 times.doi: 10.1136/bmj.4.5834.206Check SFX for full text View at Publisher60Karamizrak, S.O.Evaluation of iron metabolism indices and their relation with physical work capacity in athletes (Open Access)(1996) British Journal of Sports Medicine, 30 (1), pp. 15-19. Cited 22 times.http://bjsm.bmjjournals.com/doi: 10.1136/bjsm.30.1.15Check SFX for full text View at Publisher61Samuelson, G., Lonnerdal, B., Kempe, B., Elverby, J.-E., Bratteby, L.-E.A follow-up study of serum ferritin and transferrin receptor concentrations in Swedish adolescents at age 17 years compared to age 15(2000) Acta Paediatrica, International Journal of Paediatrics, 89 (10), pp. 1162-1168. Cited 22 times.Check SFX for full text View at Publisher62Sham, R.L., Phatak, P.D., Nemeth, E., Ganz, T.Hereditary hemochromatosis due to resistance to hepcidin: High hepcidin concentrations in a family with C326S ferroportin mutation (Open Access)(2009) Blood, 114 (2), pp. 493-494. Cited 47 times.http://bloodjournal.hematologylibrary.org/cgi/reprint/114/2/493doi: 10.1182/blood-2009-04-216226Check SFX for full text View at Publisher63De Mast, Q., Nadjm, B., Reyburn, H., Kemna, E.H.J.M., Amos, B., Laarakkers, C.M.M., Silalye, S., (...), Van Der Ven, A.J.A.M.Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection (Open Access)(2009) Journal of Infectious Diseases, 199 (2), pp. 253-262. Cited 74 times.doi: 10.1086/595790Check SFX for full text View at Publisher64Brown, K., Subramony, C., May, W., Megason, G., Liu, H., Bishop, P., Walker, T., (...), Nowicki, M.J.Hepatic iron overload in children with sickle cell anemia on chronic transfusion therapy(2009) Journal of Pediatric Hematology/Oncology, 31 (5), pp. 309-312. Cited 34 times.doi: 10.1097/MPH.0b013e3181a1c143Check SFX for full text View at Publisher65Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E.T., Swinkels, D.W., Trinder, D.Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity(2009) European Journal of Applied Physiology, 106 (1), pp. 51-59. Cited 59 times.doi: 10.1007/s00421-009-0988-7Check SFX for full text View at Publisher66Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E.T., Swinkels, D.W., Trinder, D.Training surface and intensity: Inflammation, hemolysis, and hepcidin expression(2009) Medicine and Science in Sports and Exercise, 41 (5), pp. 1138-1145. Cited 70 times.doi: 10.1249/MSS.0b013e318192ce58Check SFX for full text View at Publisher67Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E.T., Swinkels, D.W., Trinder, D.Effects of exercise on hepcidin response and iron metabolism during recovery(2009) International Journal of Sport Nutrition and Exercise Metabolism, 19 (6), pp. 583-597. Cited 59 times.http://hk.humankinetics.com/eJournalMedia/pdfs/17609.pdfdoi: 10.1123/ijsnem.19.6.583Check SFX for full text View at Publisher68Roecker, L., Meier-Buttermilch, R., Brechtel, L., Nemeth, E., Ganz, T.Iron-regulatory protein hepcidin is increased in female athletes after a marathon(2005) European Journal of Applied Physiology, 95 (5-6), pp. 569-571. Cited 82 times.doi: 10.1007/s00421-005-0055-yCheck SFX for full text View at Publisher69Adamson, J.W.The anemia of inflammation/malignancy: mechanisms and management. (Open Access)(2008) Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, pp. 159-165. Cited 59 times.doi: 10.1182/asheducation-2008.1.159Check SFX for full text View at Publisher70Dascombe, B.J., Karunaratna, M., Cartoon, J., Fergie, B., Goodman, C.Nutritional supplementation habits and perceptions of elite athletes within a state-based sporting institute(2010) Journal of Science and Medicine in Sport, 13 (2), pp. 274-280. Cited 61 times.doi: 10.1016/j.jsams.2009.03.005Check SFX for full text View at Publisher71Ziauddin Hyder, S.M., Persson, L.Å., Chowdhury, A.M.R., Ekström, E.-C.Do side-effects reduce compliance to iron supplementation? A study of daily- and weekly-dose regimens in pregnancy(2002) Journal of Health Population and Nutrition, 20 (2), pp. 175-179. Cited 77 times.Check SFX for full text View at Publisher72Ries, C.A., Santi, D.V.Agents used in anemias(1992) Basic and Clinical Pharmacology, pp. 453-459. Cited 4 times.Katzung BG, ed., Norwalk, CT Appleton & Lange 73Lauffer, R.B.Exercise as prevention: Do the health benefits derive in part from lower iron levels?(1991) Medical Hypotheses, 35 (2), pp. 103-107. Cited 29 times.doi: 10.1016/0306-9877(91)90031-SCheck SFX for full text View at Publisher Pigozzi, F.; Department of Health Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis 15, Italy; email:fabio.pigozzi@uniroma4.it © Copyright 2011 Elsevier B.V., All rights reserved. Back to results Previous 42of71 Next Top of pageMetrics Learn more about Article metrics in Scopus (opens in a new window)0 Citations in Scopus0 Field-Weighted Citation ImpactPlumX MetricsUsage, Captures, Mentions, Social Media and Citations beyond Scopus.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.