OBJECTIVE: To develop a multiple-endpoint monitoring system in order to assessand minimize long term risks in hospital nurses exposed to antiblastic drugs.DESIGN: Molecular epidemiology study.SETTING: S. Orsola-Malpighi Hospital in Bologna, Italy: nurses exposed toantiblastic drugs.PARTICIPANTS: 50 exposed subjects (8 males and 42 females) and 50 unexposedindividuals (8 males and 42 females) matched for age and smoking habits.MAIN OUTCOME MEASURES: Urinary markers of exposure, Heat Shock Proteins (HSPs)27, 70, 90, 110, immunologic biomarkers in peripheral blood lymphocytes:apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK)and receptors micronuclei; frequency in peripheral blood lymphocytes and inexfoliated buccal mucosa cells; activation ofspecific oncogenes (bax, bcl2).RESULTS: 19/50 subjects showed urinary antiblastic drug levels (3 subjects MTX,11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and controlgroups.CONCLUSION: This biomonitoring study doesn't evidence any early significanteffect associated to the exposure to antiblastic drugs.
Biomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project(Article) [Identificazione di marcatori specifici di esposizione professionale a farmaci antiblastici usati in polichemioterapia: Progetto IMEPA.]
Romano Spica V;
2005-01-01
Abstract
OBJECTIVE: To develop a multiple-endpoint monitoring system in order to assessand minimize long term risks in hospital nurses exposed to antiblastic drugs.DESIGN: Molecular epidemiology study.SETTING: S. Orsola-Malpighi Hospital in Bologna, Italy: nurses exposed toantiblastic drugs.PARTICIPANTS: 50 exposed subjects (8 males and 42 females) and 50 unexposedindividuals (8 males and 42 females) matched for age and smoking habits.MAIN OUTCOME MEASURES: Urinary markers of exposure, Heat Shock Proteins (HSPs)27, 70, 90, 110, immunologic biomarkers in peripheral blood lymphocytes:apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK)and receptors micronuclei; frequency in peripheral blood lymphocytes and inexfoliated buccal mucosa cells; activation ofspecific oncogenes (bax, bcl2).RESULTS: 19/50 subjects showed urinary antiblastic drug levels (3 subjects MTX,11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and controlgroups.CONCLUSION: This biomonitoring study doesn't evidence any early significanteffect associated to the exposure to antiblastic drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
