Liver diseases are a major health concern and affect a large proportion of people worldwide. There are over 100 types of liver disorders, including cirrhosis, cholangiocarcinoma (CCA), hepatocellular carcinoma, and hepatitis. Despite the relevant number of people who are affected by liver diseases, and the increased awareness with regard to these disorders, the number of deaths corresponding to liver injury is expected to increase in the foreseeable future. One of the possible reasons for this is that a complete comprehension of the mechanisms of hepatic damage involving specific liver anatomical districts is lacking, and, as a consequence, current treatments available are suboptimal.

Functional role of the secretin/secretin receptor signaling during cholestatic liver injury

Franchitto A.;
2020-01-01

Abstract

Liver diseases are a major health concern and affect a large proportion of people worldwide. There are over 100 types of liver disorders, including cirrhosis, cholangiocarcinoma (CCA), hepatocellular carcinoma, and hepatitis. Despite the relevant number of people who are affected by liver diseases, and the increased awareness with regard to these disorders, the number of deaths corresponding to liver injury is expected to increase in the foreseeable future. One of the possible reasons for this is that a complete comprehension of the mechanisms of hepatic damage involving specific liver anatomical districts is lacking, and, as a consequence, current treatments available are suboptimal.
2020
CCA
cholangiocarcinoma
CFTR
cystic fibrosis transmembrane conductance regulator
dnTGF-βRII
dominant-negative transforming growth factor β receptor II
Mdr2
multidrug resistance 2 (Abcb4)
miRNA
microRNA
NGF
nerve growth factor
PBC
primary biliary cholangitis
PKA
protein kinase A
PSC
primary sclerosing cholangitis
Sct
secretin0
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14244/4467
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