Prolonged administration of melatonin (1.03 mg intake per mouse per day) in Mdr2 -/- mice improves liver histology and restores the circadian rhythm by interaction with Melatonin receptor 1 (MT1) through decreased angiogenesis and increased glutathione-S transferase activity. Manipulation of clock genes/miR200b pathway by melatonin treatment may be a therapeutic option for primary sclerosing cholangitis patients.
Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model
Carpino G;Franchitto A;
2022-01-01
Abstract
Prolonged administration of melatonin (1.03 mg intake per mouse per day) in Mdr2 -/- mice improves liver histology and restores the circadian rhythm by interaction with Melatonin receptor 1 (MT1) through decreased angiogenesis and increased glutathione-S transferase activity. Manipulation of clock genes/miR200b pathway by melatonin treatment may be a therapeutic option for primary sclerosing cholangitis patients.File in questo prodotto:
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